733 NT-PROBNP CONCENTRATIONS ACROSS PULMONARY HYPERTENSION GROUPS

Abstract Background Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) are found in both pre-capillary pulmonary hypertension (PH), including arterial hypertension, PH associated with hypoxia/lung disease and chronic thromboembolic post-capillary left heart disease. We asked the question whether NT-proBNP concentrations differ among these subtypes. Methods Based on right catheterization (RHC) data collected at our institution between Jan. 2019 Dec. 2021, 146 patients were classified as no PH, isolated (iPC-PH) or combined pre- (cPC-PH) according to 2022 ESC/ERS guidelines (GL). values compared across groups by Kruskal-Wallis test Bonferroni correction. The characteristics subjects ≤ >1.100 pg/mL, a cut-off for severity proposed GL, chi-square test, T-test, Mann-Whitney appropriate. also applied hemodynamic definitions 2018 6th World Symposium (6WSPH) 2015 examined differences distribution McNemar reassessed concentrations. Results 44 (30%) did not have 38 (26%) had 18 (12%) iPC-PH, 46 (32%) cPC-PH. progressively higher from iPC-PH cPC-PH (Figure). Interestingly, 25th percentile group was 1.138 close 1.100 pg/mL cut-off. Compared ≤1.100 those larger ventricle basal diameter [50 (43-53) vs 43 (36-45) mm; p=0.02], lower TAPSE/sPAP ratio [0.21 (0.15-0.25) 0.35 (0.25-0.43), p=0.01], more often massive tricuspid regurgitation (83% 20%, p<0.001), vascular resistance [9.5 (7.6-15.1) 5.7 (2.7-7.8) WU; p=0.004], stroke volume index [28 (17-32) 36 (32-50) mL/m2; p=0.002]. proportion decreased one increased when 6WSPH GL criteria used (p trend <0.001). Nonetheless, remained similar that observed Conclusions A gradient exists groups, highest being severe overlap cPC-PH, indirectly confirming validity this biomarker discriminate PH.